Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
نویسندگان
چکیده
منابع مشابه
Starving tumors.
Essay " What is the purpose of publications?…[The] purpose of data is to support, directly or indirectly, the marketing of our product. " [1] There are many reports of medical journal articles being researched and written by or on behalf of pharmaceutical companies, and then published under the name of academics who had played little role earlier in the research and writing process [2–14]. In e...
متن کاملFrom antiangiogenesis to hypoxia: current research and future directions
Angiogenesis has long been recognized as an essential element in tumor growth. Since the conception of antiangiogenesis for cancer therapeutics, great strides have been made in understanding the molecular biology underlying angiogenesis, both in cancer and in physiology. By capitalizing on these advancements through bench-to-bedside research, potent antiangiogenic agents have been developed and...
متن کاملStarving tumors eat metabolic enzyme
Starving tumors eat metabolic enzyme Xia et al. describe a way to force cancer cells to destroy a key metabolic enzyme they need to survive. Autophagy helps cancer cells survive the stressful environment inside a tumor. However, blocking the process doesn’t kill cancer cells, so researchers have been looking for a way to make cells vulnerable to autophagy shutdown. Xia et al. used an ovarian ca...
متن کاملGene therapy strategies for tumor antiangiogenesis.
Based on the concept that solid tumors cannot grow without the generation of new blood vessels, there is growing interest in the use of antiangiogenesis agents to inhibit tumor growth. This review summarizes the concepts of using gene transfer vectors to provide high concentration of antiangiogenic proteins within an organ. While there are many challenges that must be met before antiangiogenesi...
متن کاملDDH Epidemiology Revisited: Do We Need New Strategies?
Background: Although the developmental dysplasia of the hip (DDH) is well known to pediatric orthopedists, its etiology has still remained unknown and despite dedication of a vast majority of research, the results are still inadequate and confusing. The exact incidence of DDH and its relationship with known risk factors in Iran is still unknown. Here we represent the results of one year study o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Cell
سال: 2014
ISSN: 1535-6108
DOI: 10.1016/j.ccell.2014.10.006